Graft Versus Host Disease and its Clinical Aspects Quiz

Test your knowledge on acute and chronic GVHD manifestations, mechanisms, treatment, and complications in this comprehensive quiz on immunology.

Practice Learn Test

Which of the following is NOT a common manifestation of acute graft-versus-host disease (GVHD)?

Skin rash

Nausea and vomiting

Abdominal pain and diarrhea

Hepatic dysfunction

Which of the following is a crucial risk factor for the development of graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation?

Blood type compatibility

HLA mismatch between donor and recipient

Recipient's age

Dietary factors

Which of the following organs is commonly affected in gastrointestinal graft-versus-host disease (GVHD)?

Kidneys

Liver

Lungs

Pancreas

Which type of graft-versus-host disease (GVHD) tends to occur earlier post-transplant, usually within the first 100 days?

Acute GVHD

Chronic GVHD

Subacute GVHD

Delayed GVHD

Which of the following is a common symptom of skin involvement in graft-versus-host disease (GVHD)?

Pruritus (itching)

Tinnitus

Orthopnea

Polyuria

What is the primary immunological mechanism underlying graft-versus-host disease (GVHD)?

Activation of B cells

Donor T cells attacking recipient's tissues

Suppression of natural killer cells

Antibody-mediated cytotoxicity

Which of the following is a hallmark feature of chronic graft-versus-host disease (GVHD)?

Sudden onset within 100 days post-transplant

Presence of bronchiolitis obliterans

Resolution without medical intervention

Isolated involvement of the skin

What is the primary difference between acute and chronic graft-versus-host disease (GVHD)?

Acute GVHD affects only the skin, while chronic GVHD affects multiple organs.

Acute GVHD is characterized by a gradual onset, while chronic GVHD has a sudden onset.

Acute GVHD occurs within 100 days post-transplant, while chronic GVHD occurs after 100 days.

Acute GVHD resolves spontaneously, while chronic GVHD requires lifelong treatment.

Which of the following is a risk factor associated with an increased incidence of chronic graft-versus-host disease (GVHD)?

Older age of the recipient

HLA-matched transplant

Infection with cytomegalovirus (CMV)

Short duration of immunosuppressive therapy

#10

Which of the following is a characteristic feature of acute graft-versus-host disease (GVHD) involving the liver?

Elevated bilirubin levels

Hypertension

Hypocalcemia

Decreased alkaline phosphatase levels

#11

Which immunosuppressive agent is commonly used for prophylaxis and treatment of graft-versus-host disease (GVHD)?

Corticosteroids

Antibiotics

Antivirals

Immunoglobulins

#12

Which of the following is a potential complication of chronic graft-versus-host disease (GVHD) affecting the eyes?

Cataracts

Glaucoma

Corneal ulcers

Retinal detachment

#13

What is the primary mechanism of action of extracorporeal photopheresis (ECP) in the treatment of graft-versus-host disease (GVHD)?

Inhibition of T cell activation

Stimulation of natural killer (NK) cells

Neutralization of pro-inflammatory cytokines

Induction of regulatory T cells

#14

What is the primary goal of prophylactic treatment for graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation?

To prevent infection

To eliminate malignant cells

To avoid graft rejection

To suppress donor immune responses

#15

Which of the following is a characteristic feature of chronic graft-versus-host disease (GVHD) involving the mouth?

Gingival hyperplasia

Periodontal abscess

Xerostomia

Glossitis