Clinical Case Scenarios in Internal Medicine Quiz

Challenge yourself with realistic patient scenarios. Assess and diagnose common internal medicine conditions.

#1

Which of the following is a recognized risk factor for the development of osteoporosis?

Regular weight-bearing exercise
Adequate calcium and vitamin D intake
Excessive alcohol consumption
High body mass index
#2

A 45-year-old female presents with a swollen, painful joint that is warm to touch and has limited range of motion. Laboratory analysis of joint fluid reveals a leukocyte count of 20,000/mm³ with predominantly neutrophils. What is the most likely diagnosis?

Osteoarthritis
Rheumatoid arthritis
Gout
Ankylosing spondylitis
#3

A 35-year-old male presents with recurrent episodes of painful urination, frequency, urgency, and suprapubic discomfort. Urinalysis shows pyuria and bacteriuria. What is the most likely diagnosis?

Acute pyelonephritis
Chronic kidney disease
Interstitial cystitis
Acute bacterial cystitis
#4

A 55-year-old female presents with progressive fatigue, palpitations, and unintentional weight loss. On examination, there is an enlarged thyroid gland with palpable nodules. Laboratory tests reveal elevated thyroid hormone levels. What is the most likely diagnosis?

Graves' disease
Hashimoto's thyroiditis
Toxic multinodular goiter
Subacute thyroiditis
#5

A 50-year-old male presents with a sudden onset of severe right lower quadrant abdominal pain, nausea, and vomiting. On examination, there is tenderness and guarding at McBurney's point. What is the most likely diagnosis?

Acute cholecystitis
Acute pancreatitis
Appendicitis
Diverticulitis
#6

Which of the following is a characteristic feature of Graves' disease?

Hypothyroidism
Hypocalcemia
Exophthalmos
Weight gain
#7

A 50-year-old obese male with a history of poorly controlled type 2 diabetes mellitus presents with a sudden onset of severe chest pain, diaphoresis, and dyspnea. His ECG shows ST-segment elevation in leads II, III, and aVF. What is the most likely diagnosis?

Acute pericarditis
Acute myocardial infarction
Aortic dissection
Pulmonary embolism
#8

A 30-year-old female presents with fatigue, cold intolerance, and weight gain over the past few months. On examination, there is diffuse thyroid enlargement and a bruit over the thyroid gland. Laboratory tests reveal elevated thyroid hormone levels. What is the most likely diagnosis?

Graves' disease
Hashimoto's thyroiditis
Toxic multinodular goiter
Subacute thyroiditis
#9

Which of the following medications is commonly used for the treatment of essential hypertension?

Metformin
Furosemide
Lisinopril
Warfarin
#10

A 70-year-old male presents with progressive dysphagia to solids and liquids, weight loss, and regurgitation of undigested food. What is the most likely diagnosis?

Esophageal cancer
Gastric ulcer
Gastroesophageal reflux disease (GERD)
Hiatal hernia
#11

A 45-year-old male presents with sudden-onset severe chest pain radiating to the back. On examination, blood pressure in the right arm is 180/100 mmHg, and in the left arm is 110/70 mmHg. What is the most likely diagnosis?

Myocardial infarction
Aortic dissection
Pulmonary embolism
Pericarditis
#12

A 65-year-old female presents with progressive dyspnea on exertion, fatigue, and pedal edema. She has a history of rheumatic fever. On examination, there is a loud holosystolic murmur best heard at the apex, and an S3 gallop rhythm is present. What is the most likely diagnosis?

Aortic stenosis
Mitral stenosis
Mitral regurgitation
Aortic regurgitation
#13

A 60-year-old male presents with a sudden-onset severe headache described as the 'worst headache of my life'. On examination, neck stiffness is noted. What is the most likely diagnosis?

Migraine
Subarachnoid hemorrhage
Cluster headache
Tension headache
#14

Which of the following is a typical symptom of acute pancreatitis?

Left lower quadrant abdominal pain
Jaundice
Hematemesis
Referred pain to the right shoulder
#15

A 55-year-old male presents with intermittent claudication, characterized by cramping leg pain that occurs with exercise and resolves with rest. What is the most likely diagnosis?

Peripheral artery disease
Deep vein thrombosis
Sciatica
Osteoarthritis

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