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Principles of Instrumental Analysis in Mass Spectrometry Quiz

#1

What is the primary function of the ionization source in mass spectrometry?

To generate ions from sample molecules
Explanation

Generating ions from sample molecules.

#2

Which component in mass spectrometry separates ions based on their mass-to-charge ratio?

Analyzer
Explanation

The component responsible for separating ions based on their mass-to-charge ratio.

#3

In mass spectrometry, what is the purpose of the detector?

To detect ions and measure their abundance
Explanation

Detecting ions and quantifying their abundance.

#4

Which mass spectrometry technique is commonly used for the analysis of volatile organic compounds (VOCs)?

Gas Chromatography-Mass Spectrometry (GC-MS)
Explanation

GC-MS is suited for analyzing VOCs.

#5

Which of the following is an advantage of electrospray ionization (ESI) in mass spectrometry?

High sensitivity and compatibility with biomolecules
Explanation

ESI offers high sensitivity and is suitable for biomolecules.

#6

In mass spectrometry, what does the term 'm/z' represent?

Mass-to-charge ratio of ions
Explanation

The ratio of mass to charge of ions.

#7

Which type of mass spectrometry provides information about the structure of molecules?

Tandem Mass Spectrometry (MS/MS)
Explanation

MS/MS provides structural information by fragmenting ions.

#8

What is the purpose of a collision cell in tandem mass spectrometry?

To induce collisions and fragment ions
Explanation

Inducing collisions to fragment ions for analysis.

#9

Which ionization technique is commonly used in proteomics for analyzing large biomolecules such as proteins?

Electrospray Ionization (ESI)
Explanation

ESI is widely used in proteomics for large biomolecule analysis.

#10

Which type of mass spectrometry is particularly useful for analyzing the isotopic composition of elements?

Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Explanation

ICP-MS is effective for analyzing isotopic composition.

#11

Which of the following is a soft ionization technique used in mass spectrometry?

Fast Atom Bombardment (FAB)
Explanation

FAB is a soft ionization technique in mass spectrometry.

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