Creutzfeldt-Jakob Disease Quiz

Test your knowledge on CJD with 17 questions covering symptoms, diagnosis, and epidemiology. Perfect for medical students and professionals.

#1

Which of the following is a characteristic feature of Creutzfeldt-Jakob Disease (CJD)?

Progressive memory loss
High fever
Skin rash
Muscle hypertrophy
#2

What is the usual age range for onset of symptoms in sporadic Creutzfeldt-Jakob Disease (sCJD)?

20s to 30s
40s to 50s
60s to 70s
80s to 90s
#3

Which of the following is NOT a variant of Creutzfeldt-Jakob Disease?

Sporadic CJD
Familial CJD
Iatrogenic CJD
Endemic CJD
#4

What is the average duration of illness from onset to death in sporadic Creutzfeldt-Jakob Disease?

1-2 years
3-5 years
6-12 months
2-4 weeks
#5

Which of the following is a clinical manifestation commonly seen in Creutzfeldt-Jakob Disease?

Peripheral neuropathy
Pulmonary fibrosis
Myocardial infarction
Myoclonus
#6

Which of the following is a variant form of Creutzfeldt-Jakob Disease linked to consumption of contaminated beef?

Kuru
Bovine spongiform encephalopathy (BSE)
Fatal familial insomnia (FFI)
Gertsmann-Sträussler-Scheinker syndrome (GSS)
#7

Which protein plays a central role in the pathogenesis of Creutzfeldt-Jakob Disease?

Amyloid beta
Tau
Prion
Alpha-synuclein
#8

What is the most common route of transmission for variant Creutzfeldt-Jakob Disease (vCJD)?

Consumption of contaminated beef
Airborne droplets
Sharing utensils
Vertical transmission from mother to child
#9

Which region of the brain is most severely affected in Creutzfeldt-Jakob Disease?

Cerebellum
Frontal lobe
Temporal lobe
Occipital lobe
#10

What is the mainstay of treatment for Creutzfeldt-Jakob Disease?

Antiviral drugs
Steroids
Supportive care
Surgery
#11

Which of the following is NOT a potential mode of transmission for Creutzfeldt-Jakob Disease?

Blood transfusion
Organ transplantation
Droplet inhalation
Surgical instruments
#12

What is the primary feature of Creutzfeldt-Jakob Disease on MRI scans?

Diffuse cortical atrophy
Basal ganglia calcifications
Hyperintense signals in the caudate nucleus
Cortical ribboning
#13

Which diagnostic test is typically used to confirm Creutzfeldt-Jakob Disease?

Brain biopsy
Serum antibody test
Lumbar puncture
Electroencephalogram (EEG)
#14

Which of the following is a potential risk factor for sporadic Creutzfeldt-Jakob Disease?

Genetic mutations
Exposure to prion-contaminated materials
Viral infections
Chemical toxins
#15

Which of the following is a characteristic histopathological finding in Creutzfeldt-Jakob Disease?

Amyloid plaques
Lewy bodies
Prion protein aggregates
Neurofibrillary tangles
#16

What is the estimated annual incidence rate of sporadic Creutzfeldt-Jakob Disease per million population?

1-2 cases
5-7 cases
10-15 cases
20-25 cases
#17

Which region of the world has reported the highest incidence of variant Creutzfeldt-Jakob Disease cases?

Europe
North America
Asia
Africa

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