#1
Which of the following best defines research ethics in clinical trials?
Ethical guidelines that researchers must follow while conducting experiments
ExplanationResearch ethics in clinical trials involve guidelines ensuring ethical conduct by researchers.
#2
What does 'subject vulnerability' refer to in the context of clinical trials?
The potential for subjects to be coerced or influenced unduly due to their circumstances
ExplanationSubject vulnerability in clinical trials pertains to the susceptibility of participants to undue coercion or influence.
#3
Which ethical principle focuses on the obligation to maximize benefits and minimize harm to research participants?
Beneficence
ExplanationThe principle of beneficence emphasizes maximizing benefits and minimizing harm to research participants.
#4
What ethical principle supports the concept of fair participant selection in clinical trials?
Justice
ExplanationThe principle of justice advocates for fair participant selection in clinical trials.
#5
What is the role of a clinical trial protocol?
To provide a detailed plan for the conduct of the trial
ExplanationClinical trial protocols furnish a comprehensive plan for conducting the trial.
#6
Which principle of research ethics emphasizes the importance of obtaining informed consent from trial participants?
Autonomy
ExplanationThe principle of autonomy underscores the significance of obtaining informed consent from trial participants.
#7
What is the role of an Institutional Review Board (IRB) in clinical trials?
To review and approve the research protocol to ensure ethical standards are met
ExplanationIRBs review and approve research protocols to safeguard ethical standards in clinical trials.
#8
What is the purpose of a placebo in a clinical trial?
To provide a baseline for comparison with the experimental treatment
ExplanationPlacebos in clinical trials establish a baseline for comparing the effects of experimental treatments.
#9
Which of the following is an example of therapeutic misconception in clinical trials?
Participants falsely believing they will receive superior treatment in the trial
ExplanationTherapeutic misconception occurs when participants wrongly believe they will receive superior treatment in clinical trials.
#10
What is the purpose of a Data Safety Monitoring Board (DSMB) in clinical trials?
To ensure participant safety and study integrity
ExplanationDSMBs oversee participant safety and study integrity in clinical trials.
#11
In the Belmont Report, which of the following is not one of the three basic ethical principles outlined for research involving human subjects?
Maleficence
ExplanationThe Belmont Report delineates three basic ethical principles for research involving human subjects, with 'Maleficence' not being among them.
#12
What is the primary aim of the Declaration of Helsinki?
To outline the rights of research participants
ExplanationThe Declaration of Helsinki aims to delineate the rights of research participants.
#13
What is the significance of risk assessment in clinical trials?
To assess potential risks and benefits to participants
ExplanationRisk assessment in clinical trials evaluates potential risks and benefits to participants.
#14
Which of the following is an example of undue inducement in clinical trial recruitment?
Offering a disproportionately high payment for participation
ExplanationUndue inducement in clinical trial recruitment involves offering disproportionately high payments for participation.
#15
What is the purpose of the Declaration of Geneva?
To outline the responsibilities of medical professionals towards patients
ExplanationThe Declaration of Geneva delineates the responsibilities of medical professionals towards patients.