#1
1. What is the primary cause of prion diseases?
Misfolded proteins
ExplanationMisfolded proteins cause the infectious nature of prion diseases.
#2
2. Which protein is commonly associated with prion diseases in humans?
PrP (Prion Protein)
ExplanationPrP, or Prion Protein, is commonly associated with prion diseases in humans.
#3
3. What is the process by which prions convert normal proteins into infectious forms?
Conformational change
ExplanationPrions convert normal proteins into infectious forms through conformational changes.
#4
4. Which of the following is NOT a prion disease?
Alzheimer's Disease
ExplanationAlzheimer's Disease is not classified as a prion disease.
#5
6. Which scientist first proposed the prion hypothesis?
Stanley Prusiner
ExplanationStanley Prusiner first proposed the prion hypothesis.
#6
7. What is the common feature of prion diseases regarding their pathology?
Cell death and tissue damage
ExplanationPrion diseases commonly feature cell death and tissue damage in their pathology.
#7
11. What is the normal cellular function of the PrP (Prion Protein) before misfolding?
Cellular adhesion
ExplanationBefore misfolding, the normal cellular function of PrP is cellular adhesion.
#8
5. In which part of the body are prion proteins most abundantly found?
Brain
ExplanationPrion proteins are most abundantly found in the brain.
#9
8. Which animal was initially linked to the transmission of prion diseases to humans?
Sheep
ExplanationSheep were initially linked to the transmission of prion diseases to humans.
#10
9. What is the main method of transmission of prion diseases?
Direct contact with infected tissues
ExplanationDirect contact with infected tissues is the main method of transmission of prion diseases.
#11
10. Which prion disease is associated with cannibalistic rituals in a certain population?
Kuru
ExplanationKuru is associated with cannibalistic rituals in a certain population.
#12
12. Which prion disease primarily affects deer and elk?
Chronic Wasting Disease (CWD)
ExplanationChronic Wasting Disease (CWD) primarily affects deer and elk.