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Pharmacological Considerations in Cancer Treatment and Antiretroviral Therapy Quiz

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Which of the following is a common side effect of chemotherapy drugs known as 'chemotherapy-induced peripheral neuropathy (CIPN)'?

Peripheral neuropathy

Explanation

Nerve damage resulting from chemotherapy drug treatment.

Which of the following drugs is a commonly used alkylating agent in cancer chemotherapy?

Cyclophosphamide

Explanation

Commonly used alkylating agent in cancer treatment.

Which common side effect of chemotherapy is characterized by inflammation and ulceration of the mucous membranes lining the digestive tract?

Mucositis

Explanation

Inflammation and ulceration of digestive tract mucous membranes.

Which class of drugs inhibits the enzyme topoisomerase, thereby preventing DNA replication and leading to cell death in cancer cells?

Topoisomerase inhibitors

Explanation

Inhibit topoisomerase, halting DNA replication, causing cancer cell death.

What is the primary mechanism of action of protease inhibitors in antiretroviral therapy?

Inhibition of viral assembly and maturation

Explanation

Prevent HIV assembly and maturation by inhibiting protease enzyme.

Which drug is commonly used as a first-line treatment for breast cancer and acts by competitively inhibiting estrogen binding to its receptor?

Tamoxifen

Explanation

Competitively inhibits estrogen receptor in breast cancer.

Which antiretroviral drug class includes drugs that interfere with the synthesis of viral DNA by mimicking nucleosides and incorporating into the growing DNA chain, thereby terminating chain elongation?

Nucleoside reverse transcriptase inhibitors (NRTIs)

Explanation

Mimic nucleosides, inhibit viral DNA synthesis, block chain elongation.

Which chemotherapy-related toxicity is characterized by a decrease in the number of circulating white blood cells, increasing the risk of infections?

Neutropenia

Explanation

Decrease in white blood cells, predisposing to infections.

Which antiretroviral drug class includes drugs that inhibit the enzyme integrase, preventing integration of viral DNA into the host cell genome?

Integrase inhibitors

Explanation

Prevent integration of HIV DNA into host genome by inhibiting integrase.

#10

Which mechanism of resistance is commonly associated with prolonged use of antiretroviral drugs, leading to reduced drug effectiveness?

Mutations in drug target proteins

Explanation

Changes in drug target proteins due to prolonged drug use.

#11

Which antiretroviral drug class includes drugs that block the entry of HIV into host cells by binding to the CCR5 receptor?

CCR5 antagonists

Explanation

Block HIV entry into host cells by binding CCR5 receptor.

#12

Which antiretroviral drug class includes drugs that interfere with the maturation of viral particles by blocking the cleavage of Gag and Gag-Pol polyproteins?

Maturation inhibitors

Explanation

Block cleavage of viral polyproteins, inhibiting viral particle maturation.

#13

Which antiretroviral drug class includes drugs that bind to the HIV reverse transcriptase enzyme at a site different from the active site, preventing RNA-dependent DNA polymerization?

Non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Explanation

Bind to HIV reverse transcriptase, preventing RNA to DNA polymerization at a non-active site.

Pharmacological Considerations in Cancer Treatment and Antiretroviral Therapy Quiz

Which of the following is a common side effect of chemotherapy drugs known as 'chemotherapy-induced peripheral neuropathy (CIPN)'?

Which of the following drugs is a commonly used alkylating agent in cancer chemotherapy?

Which common side effect of chemotherapy is characterized by inflammation and ulceration of the mucous membranes lining the digestive tract?

Which class of drugs inhibits the enzyme topoisomerase, thereby preventing DNA replication and leading to cell death in cancer cells?

What is the primary mechanism of action of protease inhibitors in antiretroviral therapy?

Which drug is commonly used as a first-line treatment for breast cancer and acts by competitively inhibiting estrogen binding to its receptor?

Which antiretroviral drug class includes drugs that interfere with the synthesis of viral DNA by mimicking nucleosides and incorporating into the growing DNA chain, thereby terminating chain elongation?

Which chemotherapy-related toxicity is characterized by a decrease in the number of circulating white blood cells, increasing the risk of infections?

Which antiretroviral drug class includes drugs that inhibit the enzyme integrase, preventing integration of viral DNA into the host cell genome?

Which mechanism of resistance is commonly associated with prolonged use of antiretroviral drugs, leading to reduced drug effectiveness?

Which antiretroviral drug class includes drugs that block the entry of HIV into host cells by binding to the CCR5 receptor?

Which antiretroviral drug class includes drugs that interfere with the maturation of viral particles by blocking the cleavage of Gag and Gag-Pol polyproteins?

Which antiretroviral drug class includes drugs that bind to the HIV reverse transcriptase enzyme at a site different from the active site, preventing RNA-dependent DNA polymerization?

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