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Cystic Fibrosis: Pathophysiology and Clinical Manifestations Quiz

#1

What is the primary genetic mutation associated with cystic fibrosis?

CFTR
Explanation

CFTR mutation causes cystic fibrosis.

#2

Which of the following organs is primarily affected by cystic fibrosis?

Lungs
Explanation

Lungs are primarily affected due to mucus buildup.

#3

Which of the following organs is affected by the defective CFTR protein in cystic fibrosis?

Pancreas
Explanation

Pancreas is affected due to mucus blockage.

#4

What is the primary cause of respiratory failure in cystic fibrosis patients?

Bronchiectasis
Explanation

Bronchiectasis leads to respiratory failure.

#5

Which of the following is a characteristic feature of cystic fibrosis-related diabetes (CFRD)?

Hyperglycemia
Explanation

CFRD presents with elevated blood sugar.

#6

Which of the following best describes the role of the CFTR protein in the body?

Regulating sodium and chloride transport
Explanation

CFTR regulates ion transport.

#7

Which of the following is a potential complication of cystic fibrosis-related liver disease?

Hepatomegaly
Explanation

Liver disease can lead to hepatomegaly.

#8

What is the primary mechanism underlying the salty taste of the skin in individuals with cystic fibrosis?

Increased chloride excretion
Explanation

Excessive chloride excretion causes saltiness.

#9

Which of the following best describes the pathophysiology of cystic fibrosis?

Increased mucus production causing airway obstruction
Explanation

Excessive mucus production obstructs airways.

#10

Which of the following clinical manifestations is NOT commonly associated with cystic fibrosis?

Hypertension
Explanation

Hypertension is not commonly associated.

#11

Which of the following is a characteristic feature of cystic fibrosis on chest radiography?

Hyperinflation
Explanation

Hyperinflation is commonly seen.

#12

What is the primary mechanism leading to pancreatic insufficiency in cystic fibrosis?

Obstruction of pancreatic ducts
Explanation

Duct obstruction causes insufficiency.

#13

What is the term for the diagnostic method used to identify CFTR mutations?

Genomic sequencing
Explanation

Genomic sequencing identifies mutations.

#14

Which of the following pulmonary complications is NOT typically seen in cystic fibrosis patients?

Pulmonary fibrosis
Explanation

Pulmonary fibrosis is not typical.

#15

Which of the following is a potential complication of cystic fibrosis-related malabsorption?

Hypokalemia
Explanation

Malabsorption can lead to hypokalemia.

#16

Which of the following is a common manifestation of cystic fibrosis-related liver disease?

Ascites
Explanation

Liver disease can cause ascites.

#17

What is the gold standard diagnostic test for cystic fibrosis?

Sweat chloride test
Explanation

Sweat chloride test is highly accurate.

#18

Which of the following is a common symptom of cystic fibrosis in newborns?

Jaundice
Explanation

Jaundice can occur due to liver involvement.

#19

What is the primary cause of male infertility in individuals with cystic fibrosis?

Absent vas deferens
Explanation

Absence of vas deferens causes infertility.

#20

Which of the following is a potential cause of distal intestinal obstruction syndrome (DIOS) in individuals with cystic fibrosis?

Mucus impaction
Explanation

DIOS can occur due to mucus blockage.

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