#1
Which phase of the cell cycle involves DNA replication?
S phase
ExplanationS phase is the stage in the cell cycle where DNA synthesis and replication occur.
#2
What is the primary checkpoint for cell cycle regulation?
G1/S checkpoint
ExplanationThe G1/S checkpoint monitors the integrity of DNA before allowing the cell to enter the synthesis phase.
#3
Which phase of the cell cycle follows mitosis?
G1 phase
ExplanationG1 phase follows mitosis and involves cell growth, normal functioning, and preparation for DNA synthesis.
#4
Which phase of the cell cycle is characterized by rapid cell growth and metabolic activity?
G1 phase
ExplanationG1 phase is marked by cell growth and metabolic activity in preparation for DNA synthesis.
#5
Which of the following is NOT a phase of mitosis?
Interphase
ExplanationInterphase is not a phase of mitosis; it is the overall cell cycle stage encompassing G1, S, and G2 phases.
#6
During which phase of the cell cycle do chromosomes condense and become visible?
Prophase
ExplanationProphase is the stage where chromosomes condense, becoming visible under a microscope, as a preparation for cell division.
#7
Which protein complex regulates the progression of the cell cycle by phosphorylating key proteins?
MPF
ExplanationMPF (Mitosis-Promoting Factor) is a protein complex that promotes cell cycle progression by activating various enzymes through phosphorylation.
#8
What is the function of cyclins in the cell cycle?
To activate Cdk enzymes
ExplanationCyclins activate Cyclin-dependent kinases (Cdks), facilitating their role in regulating cell cycle transitions.
#9
What is the role of the mitotic spindle during cell division?
To organize the chromosomes
ExplanationThe mitotic spindle is a structure that helps separate chromosomes during cell division, ensuring their proper distribution to daughter cells.
#10
What is the primary function of cyclin-dependent kinases (Cdks) in the cell cycle?
To phosphorylate target proteins
ExplanationCdks phosphorylate specific target proteins, regulating various stages of the cell cycle.
#11
What happens during cytokinesis in animal cells?
The cytoplasm divides into two daughter cells
ExplanationCytokinesis is the process where the cytoplasm of a parent cell is divided into two, forming two separate daughter cells.
#12
What is the function of the Anaphase-Promoting Complex/Cyclosome (APC/C) during the cell cycle?
To regulate cyclin degradation
ExplanationAPC/C regulates the degradation of cyclins, controlling the progression through different stages of the cell cycle.
#13
Which tumor suppressor protein is commonly mutated in many cancers, leading to uncontrolled cell proliferation?
p53
Explanationp53 is a tumor suppressor protein that, when mutated, can result in the loss of control over cell division, contributing to cancer.
#14
What is the function of the retinoblastoma protein (Rb) in cell cycle regulation?
To regulate progression from G1 to S phase
ExplanationRb regulates the transition from G1 to S phase by inhibiting the activity of certain proteins involved in cell cycle progression.
#15
Which of the following is NOT a potential outcome of cell cycle checkpoint activation?
DNA replication
ExplanationCell cycle checkpoint activation can lead to various outcomes, but it does not directly involve DNA replication.
#16
Which enzyme is responsible for dephosphorylating cyclin-dependent kinases (Cdks) to inactivate them?
Cdk-phosphatase
ExplanationCdk-phosphatase is an enzyme that dephosphorylates Cdks, rendering them inactive and contributing to cell cycle regulation.
#17
Which checkpoint ensures that chromosomes are properly attached to the mitotic spindle before anaphase begins?
Metaphase checkpoint
ExplanationThe metaphase checkpoint ensures proper attachment of chromosomes to the mitotic spindle before allowing the cell to progress to anaphase.