#1
Which of the following is a common indication for anticoagulant therapy?
Hypertension
Type 2 Diabetes
Atrial Fibrillation
Osteoarthritis
#2
Which laboratory test is commonly used to monitor the effectiveness of warfarin therapy?
Activated partial thromboplastin time (aPTT)
Prothrombin time (PT)
Platelet count
Complete blood count (CBC)
#3
Which of the following conditions would NOT typically warrant anticoagulant therapy?
Deep vein thrombosis (DVT)
Pulmonary embolism (PE)
Heparin-induced thrombocytopenia (HIT)
Hypertension
#4
Which of the following is NOT a common adverse effect of anticoagulant therapy?
Bleeding
Hypertension
Thrombocytopenia
Elevated liver enzymes
#5
Which of the following is a potential complication of anticoagulant therapy?
Hypertension
Hypoglycemia
Hematoma
Hyperthyroidism
#6
What is the mechanism of action of direct oral anticoagulants (DOACs)?
Inhibition of vitamin K epoxide reductase
Inhibition of factor IIa (thrombin)
Inhibition of factor Xa
Inhibition of platelet aggregation
#7
Which of the following drugs is a direct thrombin inhibitor?
Rivaroxaban
Apixaban
Dabigatran
Warfarin
#8
Which of the following anticoagulants requires routine monitoring of drug levels?
Enoxaparin
Apixaban
Dabigatran
Fondaparinux
#9
What is the mechanism of action of heparin?
Inhibition of factor IIa (thrombin)
Inhibition of factor Xa
Inhibition of platelet aggregation
Inhibition of vitamin K epoxide reductase
#10
What is the primary mechanism of action of fondaparinux?
Direct thrombin inhibition
Direct factor Xa inhibition
Indirect factor Xa inhibition via antithrombin
Inhibition of platelet aggregation
#11
What is the typical duration of anticoagulant therapy for a patient with an unprovoked deep vein thrombosis (DVT)?
3-6 months
6-12 months
12-24 months
Indefinite
#12
What is the antidote for warfarin toxicity?
Vitamin K
Protamine sulfate
Idarucizumab
Andexanet alfa
#13
Which factor is NOT a consideration when selecting the appropriate anticoagulant therapy for a patient?
Renal function
Liver function
Platelet count
Blood type
#14
Which anticoagulant agent requires renal dose adjustment?
Apixaban
Warfarin
Dabigatran
Fondaparinux
#15
What is the main advantage of direct oral anticoagulants (DOACs) over warfarin?
They have a shorter half-life
They do not require routine monitoring
They have fewer drug interactions
They have a wider therapeutic range
#16
What is the recommended anticoagulant for patients with mechanical heart valves?
Apixaban
Rivaroxaban
Warfarin
Dabigatran
#17
Which of the following is a potential advantage of using low molecular weight heparin (LMWH) over unfractionated heparin (UFH)?
More predictable anticoagulant response
Shorter half-life
No need for subcutaneous injection
Reversal agent available